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. 2018 Oct 1;9:818. doi: 10.3389/fneur.2018.00818

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Copyright © 2018 Zsuga, More, Erdei, Papp, Harsanyi and Gesztelyi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Muscle-brain crosstalk: irisin (via PGC1-α) serves as link between peripheral non-photic entrainment signals (fast, cold, exercise) and light-induced signalization in the SCN. Irisin is induced and released in the periphery, and upon its entering the hypothalamus is hypothesized to induce BDNF expression and release. BDNF by its permissive effect is able to gate the signalization in the SCN if light signal provided. The SCN in turn entrains peripheral organs via neurohumoral, hormonal, temperature, and other indirect signals. The link between irisin and BDNF in the SCN is hypothetical. BDNF, brain-derived neurotrophic factor; PGC-1α, peroxisome proliferator-activated receptor γ coactivator 1α; SCN, suprachiasmatic nucleus.