Table 3.
Distribution of CTLA4 (A/G +49) genotypes and alleles in Tunisian AIH patients and controls.
| CTLA 4 (A/G + 49) Genotypes | AIH Patients (n = 50) |
Controls (n = 100) |
p | OR (95% CI) | ||
|---|---|---|---|---|---|---|
| n | GF (%) | n | GF (%) | |||
| G/G | 14 | 28 | 9 | 9 | 0.003 | 3.93 [1.56–9.88] |
| A/G | 24 | 48 | 57 | 57 | 0.30 | – |
| A/A | 12 | 24 | 34 | 34 | 0.26 | – |
| CTLA 4 (A/G + 49) Alleles | AIH Patients |
Controls |
p | OR (95% CI) | ||
| 2n | AF (%) | 2n | AF (%) | |||
| G | 52 | 52 | 75 | 37.5 | 0.018 | 1.80 [1.11–2.93] |
| A | 48 | 48 | 125 | 62.5 | 0.018 | 0.55 [0.34–0.90] |
n: number of subjects, AIH: Autoimmune Hepatitis, GF: Genotype frequency, AF: Allelic frequency, OR: odds ratio, CI: Confidence interval. P value calculated by the Fisher exact probability test.