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Bézier curve approximation to the data of the plasma amyloid-β study. LRs of individual points of the Bézier curve are calculated as the slopes of the tangents to the points: LR = (T5y-T4y)/(T5x–T4x) (see Figure 1). At the optimal cut-off point at a composite score of 0.5 and a Aβ1−40/Aβ1−42 ratio of 25 the LR = 1.
