Skip to main content
. 2018 Jul 20;5(3):204–219. doi: 10.1016/j.gendis.2018.07.002

Figure 2.

Figure 2

The p53-MDM2 pathway and natural products inhibitors. The p53 tumor suppressor and MDM2 oncogene form an autoregulatory feedback loop. The p53 protein binds to the MDM2 P2 promoter and increases MDM2 expression. MDM2, in turn, binds to the transactivation domain of p53 and inhibits its ability to activate the transcription of its target genes. MDM2 also acts as an E3 ligase and promotes p53 ubiquitination and degradation. A number of natural products have been reported to exert their anticancer activity by inhibiting MDM2 and/or activating p53.