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. 2018 Jun 15;5(3):245–255. doi: 10.1016/j.gendis.2018.06.001

Figure 2.

Figure 2

Effects of resveratrol on protein expression of JAK2, STAT3, AKT, mTOR, p-JAK2, p-STAT3, p-AKT, p-mTOR, BCL-2, BAX, and cleaved caspase-3 at 24 h after reperfusion. (A) The protein expression of p-AKT was increased 1.66-fold in the resveratrol group compared to the vehicle group, which was partially reversed by LY294002 (PI3K inhibitor). (B) The protein expression of p-mTOR was increased 1.66-fold in the resveratrol group compared to the vehicle group, which was also partially reversed by LY294002. (C) JAK2 inhibitor AG490 significantly decreased the protein expression of p-AKT compared with the resveratrol group. (D) The effect of PI3K inhibitor LY294002 on p-JAK2 after resveratrol treatment was not significant. (E) JAK2 inhibitor AG490 significantly decreased the protein expression of p-STAT3 compared with the resveratrol group. (F) Western blot indicated significantly higher BLC-2 and lower BAX and cleaved caspase-3 in the resveratrol group than in the vehicle group. These effects were partially reversed by LY294002 and AG490. Data are presented as mean ± SEM. (*P < 0.05; n = 5 in each group).