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. 2018 Sep 4;16(5):3913–3920. doi: 10.3892/etm.2018.6692

Figure 5.

Figure 5.

Inhibition of TLR4 suppresses the TLR4/MyD88/NF-κB signaling pathway and the effects of anti-miR-140-5p on the in vitro acute lung injury model. The protein expression of (A) TLR4, (B) MyD88 and (C) NF-κB was determined by (D) western blotting assays. The protein expression of (E) TNF-α, (F) IL-1β, (G) IL-6 and (H) MPO was also evaluated. **P<0.01 vs. negative control group; ##P<0.01 vs. anti-140-5p group. miR, microRNA; Anti-140-5p, downregulation of miR-140-5p group; TLR4 i, downregulation of miR-140-5p and TLR4 inhibitor group; TLR4, Toll-like receptor 4; MyD88, myeloid differentiation primary response 88; NF-κB, nuclear factor-κB; TNF-α, tumor necrosis factor-α; IL, interleukin; MPO, myeloperoxidase.