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. 2018 Sep 3;16(5):3827–3834. doi: 10.3892/etm.2018.6677

Figure 1.

Figure 1.

(A) Western blotting was employed to assess Bcl-2, NF-κB and PD-L1 protein levels, with α-tubulin as a loading control. In MGCD0103 groups, cells were treated for 24 h with MGCD0103 at 0.5, 1 and 2 µM, with the DMSO group considered as control cells. (B and C) Bcl-2 levels decreased in a dose-dependent manner in the MGCD0103 groups compared with the control group. (D and E) NF-κB expression was higher in the MGCD0103 groups than in controls. (F and G) Similarly, PD-L1 expression was higher in the MGCD0103 group compared with control cells. Data are presented as the mean + the standard error of the mean. *P<0.05, **P<0.01, and ***P<0.001. Bcl-2, B cell lymphoma-2; NF, nuclear factor; PD-L1, programmed death-ligand 1; DMSO, dimethyl sulfoxide.