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. 2018 Oct 2;9:2289. doi: 10.3389/fimmu.2018.02289

Figure 4.

Figure 4

TGR5 deficiency promotes viral infection in vivo. (A) Determination of VSV loads in organs by standard plaque assays from Tgr5+/+- and Tgr5−/−-mice intraperitoneally infected with VSV (1 × 108 pfu per mouse) for 24 h. (B) Haematoxylin & eosin staining of lung sections from mice in (A). Scale bar, 200 μm. PBS, phosphate-buffered saline. (C) Determination of VSV loads in organs by Q-PCR from Tgr5+/+- and Tgr5−/−-mice intravenously infected with VSV (1 × 105 pfu per mouse) for 24 h. (D) Survival of 8-week-old Tgr5+/+- and Tgr5−/−-mice given intraperitoneal injections of VSV (1 × 108 pfu/g) (n = 9 per group). GAPDH was used as an internal control for Q-PCR. The data are shown as the mean ± SD. *P < 0.05; **P < 0.01; ***P < 0.001. All experiments were performed three times with similar results.