Figure 4.

DNMT3A is highly expressed in gliomas and is associated with cell proliferation. A-D. Levels of DNMT3A were analyzed in low-grade glioma (LGG) and high-grade glioma (HGG) in CGGA, TCGA, GSE4290 and Rembrandt databases. E. Western blotting was applied to detect the level of DNMT3A in clinical tissues, β-Actin was used as the loading control. F, G. Gene positively-associated with DNMT3A expression in the CGGA, Rembrandt, and GSE4290 glioblastoma samples were subjected to gene ontology (GO) analysis and KEEG pathway analysis. Enrichment for biological process in the GO database and KEGG pathways analysis are shown. The orders of the different biological processes is based on their enriched number.