Figure 4.

Effects of EPL on cardiac injury markers in STZ-isoproterenol challenged rats. A. Creatine kinase-MB (CK-MB), B. Lactate dehydrogenase (LDH). Data were expressed as the mean ± S.E.M. Significance was determined by one-way ANOVA (Analysis of variance) followed by the Bonferroni’s post hoc test: ***P<0.001 as compared to Diabetic ISO; ###P<0.001 as compared to diabetic control; $P<0.001 as compared to eplerenone. (All the animals from groups were diabetic, where ISO: Isoproterenol; EPL: Eplerenone; Wort: wortmannin; Wort + EPL: wortmanin + Eplerenone).