Table 6.
The results of meta-analysis for different postoperative side effects in various genotype models
| Genetic model | Heterogeneity test | Test of Association | Publication bias | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||||||
| Name | Side effects | Q value | d.f. | I-squared | Tau-squared | P Value | Heterogeneity | Effect model | Pooled OR | 95% CI | Z value | P value | Statistical significance | |
| Allele model (G vs. A) | Nausea | 9.96 | 7 | 29.7% | NA | 0.191 | No | Fixed | 0.922 | [0.753, 1.130] | 0.78 | 0.436 | No | No |
| Vomiting | 14.59 | 7 | 52.0% | 0.1248 | 0.042 | Yes | Random | 0.787 | [0.549, 1.128] | 1.30 | 0.192 | No | ||
| PONV | 10.18 | 4 | 60.7% | 0.1903 | 0.038 | Yes | Random | 0.929 | [0.562, 1.536] | 0.29 | 0.774 | No | ||
| Pruritus | 58.66 | 4 | 93.2% | 6.1569 | 0.000 | Yes | Random | 0.258 | [0.024, 2.830] | 1.11 | 0.268 | No | ||
| Dizziness | 2.24 | 1 | 55.3% | NA | 0.135 | No | Fixed | 1.145 | [0.700, 1.871] | 0.54 | 0.589 | No | ||
| Homozygote model (GG vs. AA) | Nausea | 7.07 | 7 | 1.0% | NA | 0.422 | No | Fixed | 0.865 | [0.553, 1.353] | 0.64 | 0.524 | No | No |
| Vomiting | 12.26 | 7 | 42.9% | NA | 0.092 | No | Fixed | 0.422 | [0.254, 0.701] | 3.33 | 0.001 | Yes | ||
| PONV | 14.36 | 4 | 72.1% | 1.5879 | 0.006 | Yes | Random | 0.854 | [0.225, 3.244] | 0.23 | 0.817 | No | ||
| Pruritus | 20.79 | 4 | 80.8% | 5.5890 | 0.000 | Yes | Random | 0.445 | [0.042, 4.749] | 0.67 | 0.502 | No | ||
| Dizziness | 0.67 | 1 | 0.0% | NA | 0.412 | No | Fixed | 1.152 | [0.426, 3.112] | 0.28 | 0.781 | No | ||
| Heterozygote model (AG vs. AA) | Nausea | 7.44 | 7 | 5.9% | NA | 0.384 | No | Fixed | 0.956 | [0.715, 1.276] | 0.31 | 0.758 | No | No |
| Vomiting | 9.03 | 7 | 22.5% | NA | 0.251 | No | Fixed | 0.912 | [0.686, 1.213] | 0.63 | 0.528 | No | ||
| PONV | 2.50 | 4 | 0.0% | NA | 0.644 | No | Fixed | 0.954 | [0.636, 1.431] | 0.23 | 0.819 | No | ||
| Pruritus | 39.27 | 4 | 89.8% | 6.6836 | 0.000 | Yes | Random | 0.248 | [0.020, 3.040] | 1.09 | 0.276 | No | ||
| Dizziness | 1.82 | 1 | 44.9% | NA | 0.178 | No | Fixed | 1.568 | [0.762, 3.226] | 1.22 | 0.222 | No | ||
| Dominant model (AG + GG vs. AA) | Nausea | 12.63 | 8 | 36.6% | NA | 0.125 | No | Fixed | 0.833 | [0.650, 1.067] | 1.45 | 0.148 | No | No |
| Vomiting | 11.53 | 8 | 30.6% | NA | 0.173 | No | Fixed | 0.765 | [0.592, 0.987] | 2.06 | 0.040 | Yes | ||
| PONV | 4.59 | 5 | 0.0% | NA | 0.468 | No | Fixed | 0.888 | [0.632, 1.248] | 0.68 | 0.494 | No | ||
| Pruritus | 55.12 | 6 | 89.1% | 4.1175 | 0.000 | Yes | Random | 0.308 | [0.057, 1.662] | 1.37 | 0.171 | No | ||
| 2.61 | 2 | 23.3% | NA | 0.271 | No | Fixed | 1.609 | [0.966, 2.681] | 1.83 | 0.068 | No | |||
| Recessive model (GG vs. AA + AG) | Nausea | 5.09 | 7 | 0.0% | NA | 0.648 | No | Fixed | 0.857 | [0.562, 1.306] | 0.72 | 0.473 | No | No |
| Vomiting | 9.31 | 7 | 24.8% | NA | 0.231 | No | Fixed | 0.439 | [0.268, 0.717] | 3.29 | 0.001 | Yes | ||
| PONV | 15.37 | 4 | 74.0% | 1.5419 | 0.004 | Yes | Random | 0.832 | [0.226, 3.062] | 0.28 | 0.782 | No | ||
| Pruritus | 14.09 | 4 | 71.6% | 3.1823 | 0.007 | Yes | Random | 0.653 | [0.096, 4.446] | 0.44 | 0.663 | No | ||
| Dizziness | 0.18 | 1 | 0.0% | NA | 0.673 | No | Fixed | 0.905 | [0.357, 2.293] | 0.21 | 0.833 | No | ||