Table III.

Univariate and multivariate analysis of clinicopathological factors for the DFS of 84 patients with breast cancer.

	Univariate analysis		Multivariate analysis
Characteristic	HR (95% CI)	P-value	HR (95% CI)	P-value
Age	0.81 (0.45–1.48)	0.387
Tumor size	1.61 (0.88–2.93)	0.119
Histological grade	2.99 (1.20–7.45)	0.018	4.46 (1.43–13.94)	0.010
Lymph node status	2.85 (1.50–5.38)	0.001	2.13 (1.07–4.56)	0.045
ER status	0.73 (0.36–1.47)	0.376
HER-2 status	1.17 (0.59–2.32)	0.654
Ki-67	3.52 (1.23–10.12)	0.019	4.61 (1.26–16.95)	0.021
POLD1	3.14 (1.67–5.91)	<0.001	2.14 (0.99–4.68)	0.048

DFS, disease-free survival; ER, estrogen receptor; HER-2, human epidermal receptor-2; POLD1, polymerase δ catalytic subunit gene.