Table IV.
Immunohistochemical staining analyses of ALDH1A1 and OCT4 expression in cervical lesions.
| A, ALDH1A1 | ||||||
|---|---|---|---|---|---|---|
| Samples | − | + | ++ | +++ | P-value | |
| NC (n=33) | 8 | 18 | 7 | 0 | <0.0001a | |
| CIN II–III (n=37) | 11 | 4 | 19 | 3 | 0.028b | |
| SCC (n=47) | 5 | 0 | 25 | 17 | <0.0001b | <0.0001c |
| B, OCT4 | ||||||
| Samples | − | + | ++ | +++ | P-value | |
| NC (n=33) | 20 | 12 | 1 | 0 | 0.001a | |
| CIN II–III (n=37) | 19 | 13 | 5 | 0 | 0.138b | |
| SCC (n=47) | 16 | 14 | 17 | 0 | <0.0001b | 0.029c |
-, negative expression; +, weak positive expression; ++, moderate positive expression; +++, strong positive expression
a
Comparison between all three groups
b
Comparison with NC
c
Comparison with CIN II–III. ALDH1A1, aldehyde dehydrogenase 1 family member A1; OCT4, POU class 5 homeobox 1; SCC, cervical squamous cell carcinoma; CIN, cervical intraepithelial neoplasia; NC, negative controls.