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Clinical correlates of total white matter lesion volume (VWML). (A) VWML is increased in DM1-affected subjects compared with controls, and is age-dependent. (B,C) Demonstrate trends toward higher reporting of depression and cognitive impairment symptoms respectively in patients with lower VMWL. (D) Demonstrates a positive relationship between VWML and everyday executive dysfunction reported by a proxy (informant-DEX).
