Table 4.
Linear regression analysis between GMV and neuropsychology assessment scores in DM1-affected participants only, demonstrating improvement with multivariate models including sex and age.
|
Age Adj R2 |
GMV Adj R2 | GMV + sex Adj R2 | GMV + sex + age | |
|---|---|---|---|---|
| STROOP TEST (T-SCORE) | ||||
| Word task | ns | 0.171 | 0.200 |
p = 0.003 Adj R2 = 0.280 |
| Color task | ns | 0.316 | 0.367 |
p < 0.001 Adj R2 = 0.399 |
| Color-word task | ns | (0.101) | 0.287 |
p < 0.001 Adj R2 = 0.353 |
| Interference | ns | ns | 0.275 |
p = 0.006 Adj R2 = 0.257 |
| D-KEFS™ TRAIL MAKING (SCALED SCORE) | ||||
| 1. Number scanning | ns | ns | ns |
p = 0.013 (Adj R2 = 0.199) |
| 2. Number sequencing | ns | ns | (0.173) |
p = 0.007 Adj R2 = 0.232 |
| 3. Letter sequencing | ns | (0.089) | 0.232 |
p = 0.002 Adj R2 = 0.276 |
| 4. Number-letter sequencing | ns | ns | (0.135) |
p = 0.043 (Adj R2 = 0.137) |
| 5. Motor | ns | ns | ns | ns |
| Motor contrast score | ns | ns | ns | ns |
| FAS WORD ASSOCIATION | ||||
| Number of words | ns | ns | ns |
p = 0.006 Adj R2 = 0.234 |
| WASI-II BLOCK DESIGN | ||||
| Standard score (T-score) | ns | ns | (0.162) |
p = 0.041 (Adj R2 = 0.140) |
| Non-adjusted score | 0.140 | (0.105) | 0.225 |
p = 0.009 (Adj R2 = 0.214) |
| ECAS | ||||
| Language | ns | ns | ns | ns |
| Verbal fluency | (0.097) | ns | ns |
p = 0.006 Adj R2 = 0.232 |
| Executive | ns | (0.124) | (0.126) | ns |
| Memory | (0.070) | ns | ns | ns |
| Visospatial | ns | ns | ns | ns |
| Total score | ns | ns | ns | ns |
ns, not significant (p > 0.05) before correction for multiple comparisons. Adj R2 values in brackets were no longer significant after Benjamini-Hochberg correction.