Table 1.
Selected series of patients treated with HFRT.
| No of Pts/BM | Volume (cm3) diameter (cm) (median) | Median dose [prescribed isodose (%)] | BEDGy10 | Median 1 year overall survival (OS) (months) (%) | 1 year local control (LC) (%) | Radionecrosis (%) | |
|---|---|---|---|---|---|---|---|
| Feuvret et al. (16) | 12 pts | 29.4 c cm3 4.4 cm |
3X7.7Gy to PTV | 39.4 | 504 days | 100% | None |
| Fokas et al. (38) | 102 pts | Gr 1: 2.04 cm3 Gr 2: 5.93 cm3 |
Gr.1(n = 61): 7X5gy Gr 2 (n = 61): 10X4Gy |
Gr 1: 52.5 Gr 2: 56 |
Gr 1: 7 mo Gr 2: 10 mo |
Gr 1: 75% Gr 2: 71% |
1 patient in Gr 1 |
| Inoue et al. (40) | 88 pts/ 92 BM |
16.2 c cm3 | Gr 1: 10–19.9 cm3: 27–30 Gy in 3 fx Gr 2: 20–29.0 cm3: 31–35 Gy in 5 fx Gr 3: >30 cm3: 35–42 Gy in 8–10 fx (55–57%) |
Gr 1: 51.3–60 Gr 2: 50.2–59.5 Gr 3: 50.7–59.6 |
9 mo | Marginal recurrences: GR 1: 7% Gr 2: 11% Gr 3: 0% |
|
| Jiang et al. (13) | 40 pts | 17.5 cm3 4.1 cm |
40 gy (20–53) in 10 fx (4–15) isodose: 90% + boost 20 gy (10–35) in 4 fx (2–10) in 23 patients 1–3 months after tx | 56 + 30 | 15 mo 55.3% |
94% | None |
| Minniti et al. (12) | 138 pts | 12.5 cm3 | 27 Gy in 3 fx (80–90%) | 51.3 | 13.4 months 56% |
90% (for lesions ≥3 cm 73%) | 9% for HFRT 14% for lesions >3 cm |
| Navarria et al. (7) | 102 pts 51 Gr 1 51 Gr 2 |
16.3 cm3 2.9 cm |
Gr 1: diameter 2.1–3 cm: 27 Gy in 3 fx Gr 2: diameter 3.1–5 cm: 32 Gy in 4 fx (80%) |
Gr 1: 51.3 Gr 2: 57.6 |
14 mo 69% Gr 1: 14 mo 60% Gr 2:14 mo 80% |
96% Gr 1: 100% Gr 2:91% |
5.8% |
| Murai et al. (6) | 54 pts/ 61 BM |
≥2.5 cm | diameter 2.5–3 cm: 3 fx diameter ≥4 cm: 5 fx Gr 1: 18–22 Gy in 3 fx 21–25 Gy in 5 fx Gr 2: 22–27 Gy in 3 fx 25–31 Gy in 5 fx Gr 3: 27–30 Gy in 3 fx 31–35 Gy in 5 fx |
Gr 1: 28.8–39.4 29.8–37.5 Gr 2: 39–51.3 37.5–50.2 Gr 3: 51.3–60 50.2–59.5 |
31% | 69% Gr1: 66% Gr 2: 65% Gr 3: 68% |
None |
| Rajakesari et al. (41) | 70 pts | 1.7 cm | 25 Gy in 5 fx (90–95%) | 37.5 | 10.7 mo | 56% | 4.3% |
| Fahrig et al. (37) | 150 pts/ 228 BM Gr 1: 72 Gr 2: 59 GR 3: 97 |
6.1 cm3 | Gr 1: 5X 6–7Gy Gr 2: 10 X 4 Gy Gr 3: 7X 5Gy (90%) |
Gr 1: 48–59.5 Gy Gr 2: 56 Gy GR 3: 52.5 Gy |
16 mo 83% Gr 2 and Gr 3: 17 mo Gr 1: 11 mo |
Gr 1: 87% Gr 2: 95% GR 3: 96% |
1.3% |
| Aoyama et al. (44) | 87 pts/ 159 BM |
35 Gy in 4 fx | 62.9 | 8.7 mo | 81% | ||
| Ernst-Stecken et al. (36) | 51 pts/ 72 BM |
2.27 cm 6 cm3 |
Gr 1: If WBRT prior: 5X 6Gy Gr 2: no WBRT: 5X 7Gy (90%) |
Gr 1: 58 Gr2: 59.5 |
11 mo | 76% | 2% |
| MULTIPLE STAGE RADIOSURGERY SERIES | |||||||
| Higuchi et al. (39) | 43 pts | 17.8 cm3 | 10 Gy in 3 fx, 2 weeks apart |
60 | 8.8 mo 76.2% |
75.9% | None |
| Yomo and Hayashi (42) | 58 pts | 16.4 cm3 | 20–30 Gy in 2 fx; 3–4 weeks apart (45%) |
40–75 | 11.8 mo 47% |
64% | None |
| Angelov et al. (3) | 54 pts/ 63 BM |
10.54 cm3 3.3 cm |
30 Gy in 2 fx 1 months apart (54%) |
75 | 10.8 49% |
88% (@ 6 mo) | 3.17% |
| Dohm et al. (35) | 33 pts/ 39 BM |
11.68 cm3 | 15 Gy in 1 fx followed a month later by 14 Gy in 1 fx (50%) |
37.5–33.6 | 60% | 87% | 10.2% |