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. 2018 Oct 2;9:1106. doi: 10.3389/fphar.2018.01106

FIGURE 2.

FIGURE 2

ADQ significantly enhances the chemosensitivity of breast cancer cells. (A) The synergistic effects of ADQ (50 μg/mL) with paclitaxel (50 ng/mL) on MDA-MB-231 and MCF-7 cells, and the inhibitory effects of ADQ (50 μg/mL) on MDA-MB-231/T and MCF-7/T cells were studied by the cell counting assay after 48h treatment (∗P < 0.05 v.s. control, ∗∗P < 0.01 v.s. control, values represented as the mean ± SD, n = 3); (B) Colony formation assay for evaluating the long-term inhibitory effects of ADQ (50 μg/mL) with or without paclitaxel (50 ng/mL) on MDA-MB-231 and MCF-7 cells; (C) Colony formation assay for evaluating the long-term inhibitory effects of ADQ (50 μg/mL) on MDA-MB-231/T and MCF-7/T cells (∗P < 0.05 v.s. control, ∗∗P < 0.01 v.s. control, values represented as the mean ± SD, n = 3); (D) the drug efflux assay revealed that ADQ (50 μg/mL) could enhance the epirubicin intake into breast cancer cells, as shown by increased fluorescence intensity of epirubicin in ADQ-treated cells by flow cytometry analysis.