Table 2.
Differences in clinical and laboratory parameters by metabolic health status: BMI < 25 kg/m2.
| Metabolically healthy | Metabolically unhealthy | P value | |||
|---|---|---|---|---|---|
| n | Median (IQR) | n | Median (IQR) | ||
| HIV− | |||||
| Age (years) | 124 | 55 (50, 62) | 9 | 59 (54, 62) | 0.41 |
| IL-6 (pg/mL) | 115 | 1.1 (0.6, 1.8) | 9 | 1.1 (1.0, 1.6) | 0.55 |
| hs-CRP (μg/mL) | 118 | 0.8 (0.4, 1.3) | 9 | 1.0 (0.3, 1.2) | 0.95 |
| sTNFRI (pg/mL) | 118 | 1075 (914, 1317) | 9 | 848 (699, 1319) | 0.25 |
| sTNFRII (pg/mL) | 118 | 5496 (4737, 6595) | 9 | 5904 (3912, 6065) | 0.34 |
| sCD163 (ng/mL) | 113 | 511 (418, 674) | 9 | 549 (323, 655) | 0.51 |
| sCD14 (ng/mL) | 111 | 1341 (1126, 1549) | 9 | 122 (1158, 1425) | 0.42 |
| Adiponectin (ng/mL) | 117 | 9441 (6955, 13399) | 9 | 3654 (3111, 5020) | 0.001 |
| Leptin (pg/mL) | 117 | 2958 (1556, 4924) | 9 | 3436 (3082, 3972) | 0.24 |
| Abdominal VAT area (cm2) | 123 | 87 (54, 118) | 9 | 145 (114, 165) | 0.002 |
| Thigh subcutaneous fat area (cm2) | 124 | 35 (26, 44) | 9 | 32 (26, 35) | 0.42 |
| HOMA-IR (mmol/L × μU/mL) | 107 | 2.0 (2.0, 3.0) | 9 | 3.0 (2.0, 4.0) | 0.03 |
|
| |||||
| HIV+ | |||||
| Age (years) | 164 | 53 (49, 59) | 42 | 57 (52, 62) | 0.02 |
| IL-6 (pg/mL) | 159 | 1.3 (0.8, 2.1) | 40 | 1.9 (1.1, 2.3) | 0.03 |
| hs-CRP (μg/mL) | 159 | 1.1 (0.5, 2.6) | 40 | 1.6 (0.8, 2.9) | 0.06 |
| sTNFRI (pg/mL) | 160 | 1151 (948, 1421) | 41 | 1416 (1171, 1811) | <0.001 |
| sTNFRII (pg/mL) | 160 | 6302 (5307, 7531) | 41 | 7126 (6343, 10,467) | 0.001 |
| sCD163 (ng/mL) | 150 | 601 (451, 807) | 37 | 699 (577, 893) | 0.12 |
| sCD14 (ng/mL) | 151 | 1728 (1517, 2015) | 35 | 1807 (1539, 2204) | 0.18 |
| Adiponectin (ng/mL) | 158 | 8375 (4850, 12,397) | 40 | 4392 (2375, 8370) | <0.001 |
| Leptin (pg/mL) | 158 | 2733 (1540, 5208) | 40 | 3995 (1764, 7720) | 0.07 |
| Abdominal VAT area (cm2) | 164 | 108 (62, 154) | 41 | 182 (139, 217) | <0.001 |
| Thigh subcutaneous fat area (cm2) | 164 | 18 (7, 31) | 41 | 10 (4, 18) | 0.001 |
| HOMA-IR (mmol/L × μU/mL) | 135 | 3.0 (2.0, 3.0) | 40 | 4.0 (3.0, 6.0) | <0.001 |
HOMA-IR: homeostatic model assessment of insulin resistance; hs-CRP: high-sensitivity C-reactive protein; IL-6: interleukin-6; IQR: interquartile range; sCD163: soluble CD163; sCD14: soluble CD14; sTNFRI-II: soluble tumor necrosis factor receptor I-II; VAT: visceral adipose tissue.