Table 3.
Differences in clinical and laboratory parameters by metabolic health status: BMI > 30 kg/m2.
| Metabolically healthy | Metabolically unhealthy | P value | |||
|---|---|---|---|---|---|
| n | Median (IQR) | n | Median (IQR) | ||
| HIV− | |||||
| Age (years) | 31 | 53 (45, 62) | 60 | 56 (51, 62) | 0.1 |
| IL-6 (pg/mL) | 30 | 1.4 (1.0, 1.8) | 53 | 2.0 (1.5, 3.0) | 0.02 |
| hs-CRP (μg/mL) | 30 | 1.4 (0.9, 3.8) | 55 | 2.7 (0.9, 5.2) | 0.39 |
| sTNFRI (pg/mL) | 30 | 1240 (1017, 1309) | 55 | 1275 (1056, 1485) | 0.45 |
| sTNFRII (pg/mL) | 30 | 6120 (4976, 6961) | 55 | 6479 (5511, 7818) | 0.27 |
| sCD163 (ng/mL) | 30 | 597 (424, 705) | 52 | 628 (503, 813) | 0.11 |
| sCD14 (ng/mL) | 30 | 1250 (1078, 1433) | 53 | 1274 (1133, 1447) | 0.49 |
| Adiponectin (ng/mL) | 30 | 6464 (4916, 7964) | 54 | 5025 (3862, 6657) | 0.02 |
| Leptin (pg/mL) | 30 | 13887 (10703, 21452) | 54 | 18829 (12350, 28725) | 0.05 |
| Abdominal VAT area (cm2) | 31 | 190 (140, 263) | 60 | 262 (202, 325) | 0.004 |
| Thigh subcutaneous fat area (cm2) | 31 | 10.5 (7.6, 17.4) | 60 | 11.5 (9.4, 14.6) | 0.82 |
| HOMA-IR (mmol/L × μU/mL) | 29 | 3.0 (2.0, 4.0) | 53 | 5.0 (4.0, 8.0) | <0.001 |
|
| |||||
| HIV+ | |||||
| Age (years) | 23 | 53 (47, 59) | 62 | 52 (47, 57) | 0.53 |
| IL-6 (pg/mL) | 23 | 1.6 (1.0, 2.3) | 58 | 1.8 (1.3, 2.5) | 0.27 |
| hs-CRP (μg/mL) | 22 | 1.4 (0.8, 2.8) | 59 | 1.7 (0.9, 3.0) | 0.36 |
| sTNFRI (pg/mL) | 23 | 1226 (1023, 1499) | 59 | 1150 (946, 1499) | 0.50 |
| sTNFRII (pg/mL) | 23 | 5751 (5008, 7785) | 59 | 6271 (5334, 7684) | 0.36 |
| sCD163 (ng/mL) | 23 | 646 (513, 793) | 58 | 686 (486, 835) | 0.76 |
| sCD14 (ng/mL) | 23 | 1453 (1336, 1672) | 58 | 1495 (1240, 1771) | 0.73 |
| Adiponectin (ng/mL) | 23 | 6167 (3876, 8089) | 60 | 4359 (3044, 5910) | 0.009 |
| Leptin (pg/mL) | 23 | 14262 (8409, 16957) | 60 | 13318 (10965, 20808) | 0.64 |
| Abdominal VAT area (cm2) | 23 | 183 (134, 242) | 62 | 267 (205, 352) | 0.001 |
| Thigh subcutaneous fat area (cm2) | 23 | 62 (41, 94) | 62 | 44 (26, 74) | 0.09 |
| HOMA-IR (mmol/L × μU/mL) | 22 | 3.0 (2.0, 4.0) | 58 | 6.0 (4.0, 10.0) | <0.001 |
HOMA-IR: homeostatic model assessment of insulin resistance; hs-CRP: high-sensitivity C-reactive protein; IL-6: interleukin-6; IQR: interquartile range; sCD163: soluble CD163; sCD14: soluble CD14; sTNFRI-II: soluble tumor necrosis factor receptor I-II; VAT: visceral adipose tissue.