Figure 1.

Somatic alterations in HCC and BTC. (A) In total, 263 variants were detected in 139 genes in the 57 patients with HCC/BTC. Of all variants detected, 225 were novel variants. (B) The comparison of mutated genes among TCGA, NCC_JP and the current HCC/BTC datasets. (C) The frequency of altered genes in the patients. (D) Of all 344 variants detected, 67.2, 18.6, 8.4 and 5.5% were SNVs, CNVs, INDELs and splices, respectively. (E) Genes with different types of mutation. (F) Of all variants detected, 85.6% had not previously been reported in the COSMIC database. (G) The heat-map for different types of variants in the patients. HCC, hepatocellular carcinoma; BTC, biliary tract cancer; SNVs, single nucleotide variants; CNVs, copy number variants; INDELs, small insertions or deletions.