Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Aug 21;16(5):5875–5881. doi: 10.3892/ol.2018.9341

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

Figure 4. — Knockdown of STAT3 significantly promotes apoptosis and suppresses cell migration and STAT3 downstream target genes in T24 cells. (A) The effects of knockdown of STAT3 on migration in T24 were analyzed using wound healing assays with a 24 h recovery period. (B) Apoptosis was determined by fluorescence-activated cell sorting. Cells in early apoptosis are in the bottom right quadrant, while cells in late apoptosis are in the top right quadrant. (C) Western blot analysis was used to detect the expression of STAT3 downstream target proteins. All data are presented as the mean ± standard deviation of the mean. *P<0.05 and **P<0.01. shRNA, short hairpin RNA; STAT3, signal transducer and activator of transcription; PI, propidium iodide; FITC, fluorescein isothiocyanate; VEGFR, vascular endothelial growth factor receptor; Bcl-2, B-cell lymphoma 2; Bcl-xl, B-cell lymphoma-extra large; Mcl-1, MCL1, Bcl2 family apoptosis regulator; cMyc, MYC proto-oncogene, BHLH transcription factor.