Table III.
Univariate and multivariate Cox proportional hazards regression analyses of factors associated with overall survival of patients (n=103) with multinodular hepatocellular carcinoma.
| Univariate | Multivariate analysis | ||
|---|---|---|---|
| Factor | P-value | HR (95% CI) | P-value |
| Tumor number (2/>2) | <0.001a | 2.985 (1.425–6.251) | 0.004a |
| Tumor size (<50/≥50 mm) | 0.215 | ||
| AFP (<100/≥100 ng/ml) | 0.144 | ||
| Microvascular invasion (no/yes) | 0.102 | ||
| Portal tumor emboli (no/yes) | 0.639 | ||
| Liver cirrhosis (no/yes) | 0.652 | ||
| MO/IM | <0.001a | 2.311 (1.087–4.914) | 0.031a |
| Adjuvant TACE (no/yes) | <0.001a | 0.331 (0.163–0.676) | 0.002a |
a
P<0.05. TACE, transcatheter arterial chemoembolization; AFP, α-fetoprotein; MO, multicentric occurrence hepatocellular carcinoma; IM, intrahepatic metastases hepatocellular carcinoma; HR, hazard ratio; CI, confidence interval.