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Representative p16INK4a immunohistochemistry results. Lack of brown staining in p16INK4a negative carcinoma at a magnification of (A) ×100 and (B) ×200. p16INK4a exhibiting diffuse nuclear and cytoplasmic brown staining in ≥70% of the tumor cells at (C) a magnification of ×100 and (D) ×200. p16INK4a, cyclin-dependent kinase inhibitor 2A.
