Table I.
Associations between p16INK4a expression and clinicopathological characteristics of patients with oral cavity and larynx squamous cell carcinoma (n=183).
| p16INK4a expressiona | |||
|---|---|---|---|
| Characteristic | Negative, n (%) | Positive, n (%) | P-value |
| Total | 137 (74.9) | 46 (25.1) | |
| Age at diagnosis, years | 0.560 | ||
| <50 | 50 (36.5) | 19 (41.3) | |
| ≥50 | 87 (63.5) | 27 (58.7) | |
| Sex | 0.360 | ||
| Male | 101 (73.7) | 37 (80.4) | |
| Female | 36 (26.3) | 9 (19.6) | |
| Smoking history | 0.156 | ||
| No | 61 (44.5) | 15 (32.6) | |
| Yes | 76 (55.5) | 31 (67.4) | |
| Alcohol consumption | 0.467 | ||
| No | 103 (75.2) | 37 (80.4) | |
| Yes | 34 (24.8) | 9 (19.6 | |
| Tumor position | 0.633 | ||
| Oral cavity | 109 (79.6) | 36 (78.3) | |
| Buccal mucosa | 8 | 2 | |
| Floor of mouth | 12 | 1 | |
| Anterior tongue | 71 | 28 | |
| Alveolar ridge | 18 | 5 | |
| Larynx | 28 (20.4) | 10 (21.7) | |
| Supraglottic | 8 | 2 | |
| Glottic | 20 | 8 | |
| Histological differentiation | 0.325 | ||
| Well | 74 (54.0) | 30 (65.2) | |
| Moderate | 49 (35.8) | 11 (23.9) | |
| Poor | 14 (10.2) | 5 (10.9) | |
| Clinical stage | 0.405 | ||
| I/II | 86 (62.8) | 32 (69.6) | |
| III/IV | 51 (37.2) | 14 (30.4) | |
| Disease recurrence | 0.025 | ||
| No | 46 (33.6) | 24 (52.5) | |
| Yes | 91 (66.4) | 22 (47.8) | |
| Recurrent tumor sites | 0.143 | ||
| Local | 36 (39.6) | 7 (30.4) | |
| Lymph node metastasis | 49 (53.8) | 16 (69.6) | |
| Distant metastasis | 6 (6.6) | 0 (0) | |
p16INK4a, Cyclin-dependent kinase inhibitor 2A.
a
p16INK4a positive expression was defined as a strong and diffuse nuclear and cytoplasmic staining in ≥70% of the tumor cells.