Table II.

Association between the positive expression of SIRT6 and NMNAT2 in colorectal carcinoma tumors as determined with immunohistochemistry with clinical and demographic patient parameters.

		SIRT6, n (%)			NMNAT, n (%)
Parameters	Patients	Negative	Positive	P-value	Negative	Positive	P-value
Total	113	88	25		31	82
Sex				0.527			0.435
Male	65	52 (80.0)	13 (20.0)		16 (24.6)	49 (75.4)
Female	48	36 (75.0)	12 (25.0)		15 (31.3)	33 (68.7)
Age, years				0.529			0.319
≤64	57	43 (75.4)	14 (24.6)		18 (31.6)	39 (68.4)
>64	56	45 (80.4)	11 (19.6)		13 (23.2)	43 (76.8)
Tumor size, cm				0.180			0.332
≤3	50	36 (72.0)	14 (28.0)		16 (32.0)	34 (68.0)
>3	63	52 (82.5)	11 (17.5)		15 (23.8)	48 (76.2)
Differentiation				0.040			0.826
Well	18	10 (55.6)	8 (44.4)		6 (33.3)	12 (66.7)
Moderate	87	72 (82.8)	15 (17.2)		23 (26.4)	64 (73.6)
Poor	8	6 (75.0)	2 (25.0)		2 (25.0)	6 (75.0)
Depth of invasion				0.040			0.023
T1	7	5 (71.4)	2 (28.6)		4 (57.1)	3 (42.9)
T2	38	24 (63.2)	14 (36.8)		15 (39.5)	23 (60.5)
T3	17	14 (82.4)	3 (17.6)		4 (23.5)	13 (76.5)
T4	51	45 (88.2)	6 (11.8)		8 (15.7)	43 (84.3)
Lymph node metastasis				0.017			0.063
N0	72	51 (70.8)	21 (29.2)		24 (33.3)	48 (66.7)
N1+2	41	37 (90.2)	4 (9.8)		7 (17.1)	34 (82.9)
Distant metastasis				0.353			0.775
M0	95	72 (75.8)	23 (24.2)		27 (28.4)	68 (71.6)
M1	18	16 (88.9)	2 (11.1)		4 (22.2)	14 (77.8)
Tumor-node-metastasis stage				0.032			0.048
I	36	22 (61.1)	14 (38.9)		16 (44.4)	20 (55.6)
II	30	25 (83.3)	5 (16.7)		5 (16.7)	25 (83.3)
III	29	25 (86.2)	4 (13.8)		6 (20.7)	23 (79.3)
IV	18	16 (88.9)	2 (11.1)		4 (22.2)	14 (77.8)

SIRT6, sirtuin 6; NMNAT2, nicotinamide mononucleotide adenylyltransferase 2.