Table III.
Accuracy of predicted clinical response in NAC cases.
| Clinical response | The present study % (n=33) | Historical control study % (n=76: M-VAC, 39; CaG, 37) | Odds ratio | 95% CI | P-value |
|---|---|---|---|---|---|
| Accuracy of the prediction system | 82.1 (23/28a) | 92.5 (37/40b) | 0.37 | 0.08 to 1.71 | 0.259 |
| The rate of predicted to be responder | 75.8 (25/33) | 57.9 (44/76) | 2.27 | 0.91 to 5.69 | 0.087 |
| Clinical response rate of NAC cases | 88.0 (22/25c) | 56.6 (43/76) | 5.63 | 1.55 to 20.42 | 0.0041d |
| The rate of surgery after NAC | 85.7 (24/28) | 75.0 (57/76) | 2.00 | 0.62 to 6.50 | 0.296 |
| The rate of downstaged (pT1≤) | 54.2 (13/24) | 63.2 (36/57) | 0.69 | 0.26 to 1.81 | 0.466 |
| The rate of pT0 | 4.2 (1/24) | 14.0 (8/57) | 0.27 | 0.03 to 2.26 | 0.268 |
Excluding
a
5 patients who declined NAC
b
36 (M-VAC 18, CaG 18) learning cases
c
3 NAC cases with negative PSs.
d
P<0.01. NAC, neoadjuvant chemotherapy; CI, confidence intervals; M-VAC, methotrexate, vinblastine, doxorubicin plus cisplatin.