Table I.
IC50 values for 5-FU in MDA468 and MDA468/FU cells in the presence of VPA.
| MDA468 cells | MDA468/FU cells | |||
|---|---|---|---|---|
| Treatment | IC50 (µM) | R. S. | IC50 (µM) | R. S. |
| Control | 5.19±1.1 | – | 84.2±0.83 | – |
| VPA, mM | ||||
| 1 | 2.89±1.6a | 1.80 | 63.4±0.72b | 1.33 |
| 5 | 1.51±0.5b | 3.44 | 17.6±1.3b | 4.78 |
The results are presented as the mean ± standard deviation (n=4).
a
P<0.05
b
P<0.01 vs. control. R.S., Relative sensitivity (the ratio of the IC50 values for 5-FU in the control divided by that of the groups treated with VPA); IC50, 50% growth inhibitory concentration; 5-FU, 5-fluorouracil; VPA, valproic acid.