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. 2018 Oct 2;9:1123. doi: 10.3389/fphar.2018.01123

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Copyright © 2018 Staurengo-Ferrari, Ruiz-Miyazawa, Pinho-Ribeiro, Fattori, Zaninelli, Badaro-Garcia, Borghi, Carvalho, Alves-Filho, Cunha, Cunha, Casagrande and Verri.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Trans-Chalcone inhibits MSU-induced mechanical hyperalgesia and edema in a dose-dependent manner. Mice were treated Trans-Chalcone (TC, 3, 10, or 30 mg/kg, p.o., 100 μl) or vehicle (Tween 80 20% plus saline) 30 min before MSU (100 μg/10 μl/knee) stimulus in the femur-tibial joint of swiss mice. (A) Mechanical hyperalgesia and (B) edema were evaluated 1, 3, 5, 7, and 15 h after MSU injection. Results are expressed as mean ± SEM, data represent a total of 12 mice per group that were obtained in two independent experiment with 6 mice per experiment. (^∗p < 0.05 vs. control group; ^#p < 0.05 vs. vehicle group, and TC 3 group, two-way ANOVA followed by Tukey’s post-test). ^∗∗p < 0.05 vs. vehicle group.