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. 2018 Oct 2;9:1123. doi: 10.3389/fphar.2018.01123

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Copyright © 2018 Staurengo-Ferrari, Ruiz-Miyazawa, Pinho-Ribeiro, Fattori, Zaninelli, Badaro-Garcia, Borghi, Carvalho, Alves-Filho, Cunha, Cunha, Casagrande and Verri.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Trans-Chalcone reduces MSU-induced IL-1β maturation in vitro. (A) To assess the effect of trans-Chalcone on NF-κB activation, BMDMs were pre-treated with 0.1–3 μM before 500 ng/mL of LPS [i.e., before priming, panel (A) and after 3 h were secondarily stimulated with MSU (450 μg/ml, i.e., activation]. (B) To assess the direct effect of trans-Chalcone on inflammasome activation, LPS-primed BMDMs were treated with 0.1–3 μM 30 min before MSU stimulation (i.e., after priming and before activation). Results are expressed as mean ± SEM, data represent the mean of 6 wells per group per experiment with three independent experiments. (^∗p < 0.05 vs. control group; #p < 0.05 vs. vehicle, one-way ANOVA followed by Tukey’s post-test).