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. Author manuscript; available in PMC: 2018 Oct 9.
Published in final edited form as: Pharmacol Res. 2017 Dec 2;129:365–374. doi: 10.1016/j.phrs.2017.11.033

Figure 5: Natural products targeting important pathways in lacrimal gland adenocystic carcinoma (LGACC).

Figure 5:

LGACCs can have high MYB expression as a result of t(6;9)(q22–23;p23–24) chromosomal translocation. MYB is inserted next to NFIB and loses its regulation by miR-15a/16 and miR-150. Celastrol inhibits MYB/p300 interactions.