Table 2.

Comparison of the results with elevated plus maze test obtained before and after social defeat stress among three groups

Parameters	Control group (n = 12)			p a	Unsusceptible group (n = 16)			p a	Susceptible group (n = 34)			p a	p b
	Before	After	Change		Before	After	Change		Before	After	Change
Time spent in arms (s)
Open arm	39.90 ± 6.36	18.89 ± 4.90	− 21.01 ± 7.72	0.020	32.77 ± 4.70	10.38 ± 3.08	− 22.38 ± 5.83	0.003	53.12 ± 4.95	5.93 ± 1.66	− 47.18 ± 4.97*†	< 0.001	0.002
Closed arm	212.43 ± 8.54	249.29 ± 9.48	36.85 ± 12.04	0.011	221.55 ± 6.68	270.98 ± 4.72	49.42 ± 8.79	< 0.001	199.25 ± 5.28	277.99 ± 2.83	78.74 ± 5.84*	< 0.001	0.002
Number of entries
Open arm	6.16 ± 1.02	2.33 ± 0.52	− 3.83 ± 1.19	0.008	7.09 ± 1.54	1.54 ± 0.65	− 5.54 ± 0.85	< 0.001	7.00 ± 0.55	1.03 ± 0.24	− 5.96 ± 0.58	< 0.001	0.275
Closed arm	14.91 ± 1.00	16.25 ± 1.23	1.33 ± 2.11	0.541	16.90 ± 1.58	11.0 ± 1.09	− 5.90 ± 1.86*	0.010	15.5 ± 0.61	9.25 ± 0.78	− 6.25 ± 0.99*	< 0.001	0.002

Data expressed as mean ± S.E.M

^aStudent’s paired t test between the data obtained before and after social defeat stress

^bOne-way ANOVA for the change

* p < 0.05 versus control group

^†p < 0.05 versus unsusceptible group