Fig. 11.

PCa risk-associated CTCF loops may sequester genes from enhancers located outside the loops. Shown is one potential model for gene activation that occurs upon deletion of a PCa risk-associated CTCF site. In this model, the entire CTCF-binding site (CBS) is removed and therefore the loop is broken, allowing an enhancer outside the original loop to increase the activity of a promoter located within the original loop