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. 2017 Oct 30;67(11):1942–1949. doi: 10.1136/gutjnl-2017-314026

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Test and validation of the four gene candidates in a Cytosponge cohort. TFPI2, TWIST1, ZNF345 and ZNF569 were significantly hypermethylated in a pilot Cytosponge cohort (A) from patients with Barrett’s oesophagus compared with those from control patients (***p<0.0001). The pilot cohort included 20 Barrett’s oesophagus and 10 controls. Results were confirmed in a larger Cytosponge cohort from the BEST2 study (B) (***p<0.0001). The validation cohort had 149 Barrett’s oesophagus and 129 controls. (C) ROC curves for selected methylated genes in the validation Cytosponge cohort using thresholds identified in the pilot cohort. ROC, receiver operating characteristic.