Table 1.
Patient demographics of pilot and validation Cytosponge cohorts
| Controls | Cases | Pilot | Validation | |||||
| Characteristic | Pilot cohort | Validation cohort | p Value | Pilot cohort | Validation cohort | p Value | (Controls vs cases) | (Controls vs cases) |
| (n=10) | (n=129) | (n=20) | (n=149) | p Value | p Value | |||
| Age (years, median (IQR)) | 48.0 (39.0–61.0) | 55.0 (43.0–63.0) | 0.2985 | 66.0 (58.0–75.0) | 65.0 (56.0–72.0) | 0.4771 | 0.003 | <0.0001 |
| Gender (n (%)) | ||||||||
| Female | 7 (70.0) | 72 (55.8) | 0.5884 | 6 (30.0) | 27 (18.1) | 0.3381 | 0.09 | <0.0001 |
| Male | 3 (30.0) | 57 (44.2) | 14 (70.0) | 122 (81.9) | ||||
| Ethnicity (n (%)) | 0.4654 | 0.6611 | 0.28 | 0.2149 | ||||
| White British | 9 (90.0) | 113 (87.6) | 19 (95) | 139 (93.3) | ||||
| Other white background | 0 | 11 (8.5) | 1 (5) | 5 (3.4) | ||||
| Asian | 1 (10.0) | 2 (1.6) | 0 | 5 (3.4) | ||||
| African | 0 | 2 (1.6) | 0 | 0 | ||||
| Other | 0 | 1 (0.8) | 0 | 0 | ||||
| Body mass index (kg/m2, median (IQR)) | 27.7 (24.0–29.2) | 27.4 (24.5–30.4) | 0.6531 | 28.3 (25.2–29.9) | 28.4 (25.7–30.8) | 0.6143 | 0.67 | 0.106 |
| Waist:hip (median (IQR)) | 0.87 (0.81–0.88) | 0.87 (0.82–0.94) | 0.5227 | 0.92 (0.90–0.95) | 0.95 (0.92–0.99) | 0.06754 | 0.002 | <0.0001 |
| Hiatus hernia | 3 (30%) | 46 (35.7%) | 0.9722 | 17 (85%) | 118 (79.2%) | 0.7557 | 0.009 | <0.0001 |
| Barrett’s length | ||||||||
| C (cm) | – | – | 3.0 (0.4–6.3) | 2.0 (1.0–5.0) | 0.8188 | |||
| M (cm) | – | – | 5.0 (3.0–7.0) | 4.0 (3.0–7.0) | 0.7306 | |||