Appendix 2.
Model parameters used fin probabilistic analysis.
| Parameters | Mean | SD | distribution | alpha | beta |
|---|---|---|---|---|---|
| Probabilities | |||||
| PTNS ⩾50% improvement | 0.6200 | 0.0300 | beta | 161.6822 | 99.0956 |
| Proceeding to permanent SNS | 0.7350 | 0.1500 | beta | 5.6277 | 2.0290 |
| SNS_⩾50% improvement | 0.7750 | 0.0350 | beta | 109.5439 | 31.8031 |
| Adverse events for temporary SNS | 0.2039 | 0.0828 | beta | 4.6281 | 18.0740 |
| Adverse events for permanent SNS | 0.2487 | 0.0625 | beta | 11.6484 | 35.1864 |
| QALY | |||||
| PTNS ⩾50% improvement | 3.3743 | 0.5087 | normal | 44.0037 | 13.0407 |
| PTNS discontinued | 2.8793 | 0.3233 | normal | 79.3048 | 27.5434 |
| Temporary SNS_adverse_no_implant | 2.8710 | 0.3191 | normal | 80.9752 | 28.2043 |
| QALY_TempSNS_no_adverse_no_implant | 2.8793 | 0.3233 | normal | 79.3048 | 27.5434 |
| QALY_PermSNS_adverse2_improved | 3.3579 | 0.4989 | normal | 45.3080 | 13.4931 |
| QALY_PermSNS_adverse2_not_improved | 2.8628 | 0.3148 | normal | 82.6991 | 28.8878 |
| QALY_PermSNS_adverse1_improved | 3.3743 | 0.5087 | normal | 44.0037 | 13.0407 |
| QALY_PermSNS_adverse1_not_improved | 2.8710 | 0.3191 | normal | 80.9752 | 28.2043 |
| QALY_PermSNS_no_adverse_not_improved | 2.8793 | 0.3233 | normal | 79.3048 | 27.5434 |
| QALY_PermSNS_no_adverse_improved | 3.3743 | 0.5087 | normal | 44.0037 | 13.0407 |
| Costs PTNS | |||||
| ⩾50% improvement | 4,040.61 | 715.54 | gamma | 31.8881 | 0.0079 |
| No improvement | 2,364.21 | 422.01 | gamma | 31.3860 | 0.0133 |
| Discontinued | 607.49 | 30.62 | gamma | 393.7170 | 0.6481 |
| Costs SNS | |||||
| Temporary SNS, no adverse events | 1,562.94 | 190.97 | gamma | 66.9787 | 0.0429 |
| Temporary SNS, adverse events | 2,229.23 | 358.08 | gamma | 38.7578 | 0.0174 |
| Permanent SNS, no adverse events, ⩾50% improvement | 14,103.89 | 2,525.38 | gamma | 31.1906 | 0.0022 |
| Permanent SNS, no adverse events, no improvement | 13,267.37 | 2,363.65 | gamma | 31.5067 | 0.0024 |
| Temporary SNS with adverse events + permanent SNS with adverse events, ⩾50% improvement | 18,150.79 | 3,898.14 | gamma | 21.6808 | 0.0012 |
| Temporary SNS with adverse events + permanent SNS with adverse events, no improvement | 17,314.27 | 3,736.41 | gamma | 21.4733 | 0.0012 |
| Temporary SNS with adverse events + permanent SNS no adverse events, ⩾50% improvement | 14,770.18 | 2,692.45 | gamma | 30.0937 | 0.0020 |
| Temporary SNS with adverse events + permanent SNS no adverse events, no improvement | 13,933.66 | 2,530.72 | gamma | 30.3140 | 0.0022 |
| Temporary SNS no adverse events + permanent SNS with adverse events, ⩾50% improvement | 17,484.51 | 3,731.08 | gamma | 21.9603 | 0.0013 |
| Temporary SNS no adverse events + permanent SNS with adverse events, no improvement | 16,647.98 | 3,569.34 | gamma | 21.7544 | 0.0013 |
| Costs PTNS+SNS | |||||
| PTNS + temporary SNS, no adverse events | 3,927.15 | 521.86 | gamma | 56.6305 | 0.0144 |
| PTNS + temporary SNS, adverse events | 4,593.44 | 643.92 | gamma | 50.8871 | 0.0111 |
| PTNS + permanent SNS, no adverse events, ⩾50% improvement | 16,468.11 | 2,697.60 | gamma | 37.2677 | 0.0023 |
| PTNS + permanent SNS, no adverse events, no improvement | 15,631.58 | 2,537.74 | gamma | 37.9412 | 0.0024 |
| PTNS + temporary SNS with adverse events + permanent SNS with adverse events, ⩾50% improvement | 20,515.01 | 4,060.83 | gamma | 25.5219 | 0.0012 |
| PTNS + temporary SNS with adverse events + permanent SNS with adverse events, no improvement | 19,678.49 | 3,899.93 | gamma | 25.4607 | 0.0013 |
| PTNS + temporary SNS with adverse events + permanent SNS no adverse events, ⩾50% improvement | 17,134.39 | 2,863.45 | gamma | 35.8063 | 0.0021 |
| PTNS + temporary SNS with adverse events + permanent SNS no adverse events, no improvement | 16,297.87 | 2,703.40 | gamma | 36.3447 | 0.0022 |
| PTNS + temporary SNS no adverse events + permanent SNS with adverse events, ⩾50% improvement | 19,848.72 | 3,894.26 | gamma | 25.9786 | 0.0013 |
| PTNS + temporary SNS no adverse events + permanent SNS with adverse events, no improvement | 19,012.20 | 3,733.41 | gamma | 25.9331 | 0.0014 |