Table 1.

Cross-overs show strong negative interference in tel1 mutants

Strain	Crossover interval 1, %*	Crossover interval 2, %†	Double crossover observed, %	Double crossover expected, %	Interference‡
tel1+	3.76 ± 0.26	17.5 ± 2.1	0.49 ± 0.081	0.67 ± 0.11	0.26 ± 0.051§
tel1Δ	3.02 ± 0.14	8.0 ± 0.54	0.47 ± 0.048	0.245 ± 0.025	−0.90 ± 0.048

In five (tel1⁺) and eight (tel1Δ) independent crosses, crossover recombination was assayed in the ura2 – leu2 – lys7 intervals (1 and 2, respectively), each of which contains a strong Rec25, Rec27-bound DSB hotspot (4, 12). Data are mean ± SEM. See SI Appendix, Table S2A for individual data and SI Appendix, Table S2 B and C for additional data. Bold face indicates mean values.

^*Interval 1 is ura2 – leu2 on Chr 1.

^†Interval 2 is leu2 – lys7 on Chr 1.

^‡Interference = 1 – (double crossover observed/double crossover expected).

^§The near-zero values for most intervals reported by Munz (23) may not be significantly different from the value reported here, since many fewer recombinants were reported by Munz than were observed here. Two intervals showed weak but significant positive interference (I = 0.33 and 0.29).