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. 2018 Sep 19;9:1238. doi: 10.3389/fphys.2018.01238

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Copyright © 2018 Liu, Liang, Que, Zhou, Zheng and Mardinoglu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dose-response relationship between circulating adiponectin levels and metabolic syndrome risk. (A) Evaluation of association between circulating ADPQ and MetS risk in all cohorts based on restricted cubic splines and generalized least squares dose-response models; (B) Evaluation of association between circulating ADPQ and MetS risk in male cohorts based on restricted cubic splines and generalized least squares dose-response models. The solid and long-dashed curves represent instant estimates of the OR and its 95% CI for MetS risk based on the subgroup with the lowest average ADPQ level based on the restricted cubic splines model. The short-dashed line represents the estimates of the OR for MetS risk based on the subgroup with lowest average ADPQ level using the generalized least squares model. ADPQ, adiponectin; CI, confidence interval; MetS, metabolic syndrome; OR, odds ratio.