Table 1.
Characteristics of enrolled studies for accuracy of circulating adiponectin level on metabolic syndrome diagnosis.
| Population | Adiponectin | MetS | Accuracy | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Data source (Author, year, country) | Study design | Charac-teristics | Age | Gender (F/M) | Sample | Assay | Diagnosis | Prevalence (N, %) | Sensitivity | Speciality | Cut-off (ug/ml) | AUROC |
| Ogawa et al., 2005, Japan | Cross-sectional | 1. Obese adolescents, 2. Without DM, renal and here-ditary disease, 3. Without smoking and regular medication |
11.0 ± 1.3 | 0/100 | Serum | RIA | Japanese Criteria | 39(39.0) | 0.64 | 0.67 | 6.65 | 0.67 ± 0.06 |
| Gilardini et al., 2006, Italy | Cross-sectional | 1.Obese adolescents | 14(9–18) | 96/66 | Serum | ELISA | WHO definition | M:20(30.3) | 0.82(0.48–0.98) | 0.57(0.39–0.74) | 8.1 | 0.70 ± 0.05 |
| F:20(20.8) | 0.77(0.46–0.95) | 0.79(0.67–0.88) | 8.3 | 0.87 ± 0.05 | ||||||||
| Mojiminiyi et al., Kuwait 2007 | Cross-sectional | T2DM patients | MetS-M: 60(50–66) F:62(56–66) Non-MetS- M:65(59–70) F: 59 (54–65) |
78/57 | Plasma | ELISA | AHA/NHLBI criteria | M:36(63.2) | 0.83 | 0.65 | 18 | 0.74 (0.64–0.84) |
| F:46(59.0) | 0.92 | 0.41 | ||||||||||
| Lee et al., USA, 2008 | Cross-sectional | 1. obese adolescents without medication affecting lipid and BP; 2. with less (< 10%) PCOS and DM cases |
AA:12.7 ± 0.2 | AA: 74/48 | Serum | RIA | Modified NCEP-ATP-III criteria for children | AA:23(18.9) | 0.83 | 0.82 | AA: 10.8 | 0.89 |
| CA: 13.1 ± 0.2 | CA: 71/58 | CA: 24(18.6) | 0.79 | 0.79 | CA: 11.0 | 0.86 | ||||||
| Boyraz et al., Turkey, 2013 | Cross-sectional | 1. Obese pubertal children, 2. without medication for DM or dyslipide-mia |
M:12.5 ± 1.9 F:12.2 ± 2.3 |
85/63 | Serum | ELISA | Modified WHO criteria for children | 35(23.6) | 0.74 | 0.81 | 2.85 | 0.82(0.74–0.90) |
| Hata et al., Japan, 2015 | Pros-pective study | 1. General population, 2. without MetS at baseline |
40.4 ± 0.5 | 0/365 | Serum | RIA | Interim criteria | 45(12.3) | 0.73 | 0.62 | 6.2 | NA |
| Patel et al., India, 2015 | Cross-sectional | 1. General population, 2. Without ischemic, renal, liver diseases and cancer, 3. Without taking alcohol, tobacco and medication for chronic disease. |
MetS: 50.7 Non-MetS: 49.3 |
41/46 | Serum | ELISA | Interim criteria | 44(50.6) | 0.73 | 0.56 | 17.7 | 0.68(0.58–0.76) |
AA, African American; AUCROC, area under the receiver operating characteristic; CA, Caucasian; ELISA, enzyme-linked immunoabsorbent assay; F, female; M, male; MetS, metabolic syndrome; RIA, radioimmuno assay; T2DM, type 2 diabetes mellitus.