Table 3.
Subgroup analysis for accuracy of adiponectin test on diagnosis of metabolic syndrome.
| Sensitivity | Specificity | Joint effect | ||||||
|---|---|---|---|---|---|---|---|---|
| N | Mean (95%CI) | I2(%) | P | Mean (95%CI) | I2(%) | P | P | |
| AGE | ||||||||
| < 18 | 6 | 0.76(0.68–0.82) | 9.1 | 0.76(0.72–0.80) | 66.5 | |||
| >18 | 4 | 0.80(0.73–0.86) | 58.4 | 0.52 | 0.60(0.55–0.64) | 49.0 | 0.01 | 0.08 |
| GENDER | ||||||||
| Male | 4 | 0.74(0.66–0.81) | 25.8 | 0.62(0.57–0.67) | 0 | |||
| Female | 2 | 0.86(0.76–0.94) | 65.5 | 0.68(0.58–0.76) | 93.2 | |||
| Mixed | 4 | 0.78(0.70–0.85) | 0 | 0.78 | 0.78(0.73–0.82) | 74.5 | 0.20 | 0.11 |
| DM COHORT | ||||||||
| Yes | 2 | 0.88(0.79–0.94) | 15.9 | 0.51(0.37–0.65) | 71.4 | |||
| No | 8 | 0.75(0.69–0.80) | 0 | 0.04 | 0.70(0.67–0.73) | 82.2 | 0.17 | 0.02 |
| BASELINE ADPQ VALUE (ug/ml) | ||||||||
| < 10 | 5 | 0.74(0.66–0.81) | 12.6 | 0.68(0.65–0.72) | 85.2 | |||
| >10 | 5 | 0.82(0.75–0.87) | 35.2 | 0.24 | 0.70(0.64–0.75) | 82.8 | 0.79 | 0.38 |
| BASELINE HOMA-IR | ||||||||
| < 5 | 8 | 0.77(0.70–0.83) | 0.63(0.53–0.73) | |||||
| >5 | 2 | 0.85(0.72–0.94) | 0 | 0.33 | 0.80(0.74–0.86) | 0 | 0.07 | 0.03 |
| MEAN BMI | ||||||||
| < 30 | 6 | 0.76(0.70–0.81) | 26.8 | 0.68(0.64–0.71) | 79.7 | |||
| >30 | 4 | 0.82(0.74–0.88) | 41.7 | 0.38 | 0.71(0.65–0.77) | 88.0 | 0.66 | 0.54 |
| SAMPLE SIZE | ||||||||
| < 100 | 5 | 0.81(0.75–0.87) | 35 | 0.63(0.56–0.69) | 77.1 | |||
| >100 | 5 | 0.82(0.76–0.87) | 21.2 | 0.30 | 0.65(0.59–0.71) | 79.3 | 0.08 | 0.09 |
| ADPQ CUT-OFF (ug/ml) | ||||||||
| < 10 | 5 | 0.72(0.65–0.79) | 0 | 0.67(0.64–0.71) | 81.7 | |||
| >10 | 5 | 0.83(0.77–0.89) | 31.1 | 0.07 | 0.72(0.66–0.77) | 85.2 | 0.92 | 0.10 |
| MetS PREVALANCE (%) | ||||||||
| < 35 | 6 | 0.78(0.71–0.84) | 0 | 0.71(0.68–0.74) | 85.7 | |||
| >35 | 4 | 0.78(0.71–0.84) | 72.8 | 0.98 | 0.59(0.51–0.66) | 55.9 | 0.13 | 0.20 |
| SPECIMEN | ||||||||
| Serum | 8 | 0.75(0.69–0.80) | 0 | 0.70(0.67–0.73) | 82.2 | |||
| Plasma | 2 | 0.88(0.79–0.94) | 15.9 | 0.04 | 0.51(0.37–0.65) | 71.4 | 0.17 | 0.02 |
| METHODS | ||||||||
| ELISA | 6 | 0.80(0.74–0.85) | 28.7 | 0.69(0.64–0.74) | 82.7% | |||
| RIA | 4 | 0.75(0.66–0.82) | 43.7 | 0.45 | 0.69(0.65–0.73) | 86.2% | 0.37 | 0.42 |
ADPQ, adiponectin; BMI, body mass index; DM, diabetes mellitus; ELISA, enzyme-linked immunoabsorbent assay; HOMA-IR, homeostasis model assessment of insulin resistance; MetS, metabolic syndrome; RIA, radioimmuno assay.