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. 2018 Sep 19;9:1035. doi: 10.3389/fphar.2018.01035

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Copyright © 2018 Munawar, Windley, Tse, Todd, Hill, Vandenberg and Jabeen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) 2D structure of selected compound from ChemBridge database. (B) Step ramp protocol. (C) Plot of current (pA) traces vs. time(s): Green sweep is showing maximum current passing through the channel when no drug is applied to the channel. The gradual decrease in current peak is showing channel inhibition in response to various dose concentrations. (D) Dose-response curve showing percentage blockade of hERG current against various drug concentration.