Figure 2.

Predictive Measures of CAD Using the metaGRS and Conventional Risk Factors

(A) Positive predictive values versus sensitivity for the reference model (sex + age + array + 10 genetic PCs) and when adding the metaGRS to the model for all CAD in the UKB testing set. (B) C-index for sex-stratified age-as-time-scale Cox regression of incident CAD for conventional risk factors individually and in combination with the metaGRS, including genotyping array and 10 genetic PCs as covariates. APRC = area under the precision-recall curve; other abbreviations as in Figure 1.