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. 2018 Oct 4;175(2):372–386.e17. doi: 10.1016/j.cell.2018.08.067

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© 2018 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Figure S4 — Murine DSS Challenge, Related to Figures 3 and 4

Colonic stromal cells were isolated from age and sex matched Ctrl mice or mice treated with DSS for 7 days.

(A) Ratio of large bowel weight to length by treatment group. Measurements were made post-mortem on study day 7.

(B) A composite score of in-life disease activity measures (comprising weight loss, diarrhea and rectal bleeding) for all treatment groups. Group means are indicated (cross-bars).

(C) An immunologically specialized fibroblast subset analogous to human Stromal 4 is identified in the murine DSS model. Cross-tabulation of human Stromal 4 marker genes against marker genes for the 8 clusters of fibroblast-like cells identified in the DSS dataset. The number of shared markers and p value (Fisher’s Exact Test) are shown. Color scale −log(p value).