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. 2018 Jan 18;24(2):361–379. doi: 10.1093/ibd/izx014

FIGURE 9.

FIGURE 9.

Therapeutic effects of antibiotic treatment and/or fecal microbiota transplant in mice with preexisting colitis. Treatment with antibiotics (ABX; neomycin and vancomycin; N = 7), fecal microbial transplant (FMT; N = 8) or both ABX and FMT (N = 5) began 4 weeks following T cell transfer as described in the Methods section. Seven mice were not treated and served as the control group. A, Blinded histopathology scores of colons for all treatment groups at 11 weeks post T cell transfer. Data are expressed as the mean±SEM. B,. Representative micrographs from each group. Note the extensive inflammatory infiltrate (blue circles) and goblet cell dropout in the control (untreated) and FMT groups. Scores in each micrograph (in white) represent the mean histopathology scores for that group. C, Relative abundance of the 5 major phyla in feces obtained from mice subjected to ABX and/or FMT treatment. Note the large expansion of Proteobacteria and major reductions of Bacteroidetes and Verrucomicrobia in mice treated with the ABX cocktail.