. Author manuscript; available in PMC: 2018 Oct 9.

Published in final edited form as: Mod Pathol. 2016 Oct 7;30(1):60–68. doi: 10.1038/modpathol.2016.159

Table 3. Cox proportional hazards regression for 5hmC and other prognostic factors.


			Univariable		Multivariable

	n		HR(95% CI)	P value	HR(95% CI)	P value

MFS^a

5hmC	37	Score 0	1		1
	102	Score 1-2	0.40 (0.23-0.69)	0.001	0.50 (0.27-0.93)	0.02
	61	Score 3-4	0.10 (0.04-0.24)	5.0x10^-7	0.16 (0.06-0.43)	0.0002

Age	200	Years	1.02 (1.01-1.04)	0.007	0.99 (0.98-1.01)	0.47

Sex	99	Female	1
	101	Male	1.08 (0.65-1.78)	0.78	1.34 (0.75-2.38)	0.32

Site	109	Central	1		1
	91	Peripheral	1.30 (0.79-2.15)	0.30	1.15 (0.63-2.09)	0.65

Breslow depth	200	millimetres	1.10 (1.07-1.13)	4.24x10^-12	1.01 (0.97-1.06)	0.60

Mitotic rate	200	Mitoses/mm²	1.13 (1.10-1.16)	<2x10^-16	1.05 (1.01-1.09)	0.007

Ulcer	154	No	1		1
	46	Yes	8.64 (5.13-14.53)	4.44x10^-16	5.00 (2.43-10.18)	0.00001

Microsatellite	194	No	1		1
	6	Yes	3.53 (1.10-11.33)	0.03	1.18 (0.35-3.98)	0.79

MSS^b

5hmC	37	Score 0	1		1
	102	Score 1-2	0.33 (0.18-0.60)	0.0003	0.43 (0.21-0.86)	0.02
	61	Score 3-4	0.09 (0.03-0.24)	1.67x10^-6	0.19 (0.07-0.56)	0.002

Age	200	Years	1.03 (1.01-1.05)	0.006	1.00 (0.98-1.02)	0.96

Sex	99	Female	1
	101	Male	1.21 (0.70-2.10)	0.50	1.56 (0.83-2.95)	0.17

Site	109	Central	1
	91	Peripheral	1.52 (0.87-2.64)	0.14	1.51 (0.77-2.96)	0.23

Breslow depth	200	millimetres	1.12 (1.09-1.15)	9.44x10-15	1.02 (0.98-1.07)	0.41

Mitotic rate	200	Mitoses/mm²	1.14 (1.11-1.17)	<2x10^-16	1.06 (1.02-1.11)	0.007

Ulcer	154	No	1
	46	Yes	10.41 (5.87-18.48)	1.22x10^-15	5.16 (2.34-11.40)	0.00005

Microsatellite	194	No	1
	6	Yes	4.66 (1.44-15.09)	0.01	1.86 (0.54-6.47)	0.33

OS^c

5hmC	37	Score 0	1		1
	102	Score 1-2	0.46 (0.28-0.77)	0.003	0.55 (0.31-0.98)	0.04
	61	Score 3-4	0.16 (0.08-0.32)	6.02x10^-7	0.10 (0.36-0.72)	0.01

Age	200	Years	1.05 (1.03-1.07)	7.43x10^-8	1.03 (1.01-1.04)	0.009

Sex	99	Female	1
	101	Male	1.43 (0.92-2.24)	0.11	1.64 (0.97-2.79)	0.07

Site	109	Central	1
	91	Peripheral	1.12 (0.72-1.74)	0.62	1.11 (0.64-1.92)	0.72

Breslow depth	200	millimetres	1.12 (1.09-1.14)	<2x10^-16	1.03 (0.99-1.07)	0.19

Mitotic rate	200	Mitoses/mm²	1.13 (1.11-1.16)	<2x10^-16	1.08 (1.04-1.12)	0.00001

Ulcer	154	No	1
	46	Yes	6.65 (4.26-10.4)	<2x10^-16	2.15 (1.17-3.97)	0.01

Microsatellite	194	No	1
	6	Yes	6.84 (2.94-15.9)	7.92x10^-6	2.70 (1.10-6.59)	0.03

Metastasis-free survival.

Melanoma-specific survival.

Overall survival.