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. 2018 Sep 15;7(9):bio031856. doi: 10.1242/bio.031856

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© 2018. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 3. — Pathways involved in glyoxylate metabolism. Three pathways generate glyoxylate: glycolate metabolism, acetate metabolism and purine degradation. Glyoxylate enters the central metabolism through two pathways: direct conversion to malate by malate synthase G (GlcB) and/or malate synthase A (AceB) or conversion to 3-phosphoglycerate by glyoxylate carboligase (Gcl), tartronate semialdehyde reductase (GlxR) and glycerate kinase (GlxK). Genes with blue backgrounds were upregulated in ZG2 (icdA^NAD) and ZG3 (icdA^NADPΔudhA). ACO, aconitase; AllB, allantoinase; AllC, allantoate amidohydrolase; AllA, ureidoglycolate hydrolase; CS, citrate synthase; FUM, fumarase; Gcl, glyoxylate carboligase; GlxK, glycerate kinase; GlxR, tartronic semialdehyde reductase; ICL, Isocitrate lyase; KDH, α-Ketoglutarate dehydrogenase; MDH, malate dehydrogenase; SCS, Succinyl-CoA synthetase; SDH, succinate dehydrogenase.