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Etoposide or cisplatin treatment induces gems. HeLa cells were treated with etoposide or cisplatin, followed by fixation and detection of coilin (green) and SMN (red). DAPI was used to stain the nucleus (blue). CBs are represented by arrows. Double arrowheads represent gems. Single arrowheads represent nucleolar accumulation of coilin. Double arrows indicate coilin foci with low levels of SMN.
