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. 2018 Aug 28;11(9):dmm031534. doi: 10.1242/dmm.031534

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© 2018. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 7. — RERE regulates the expression of GATA4 in the AV canal. (A,B) GATA4 was visualized with anti-GATA4 antibodies on sections through the AV canals of wild-type embryos and Rere^om/eyes3 embryos. The immunoreactivity of GATA4 in the wild-type AV endocardial cushions was stronger than that observed in Rere^om/eyes3 AV endocardial cushions. (C,D) In contrast, the levels of GATA4 expression were comparable in the AV canals of Rere^flox/flox and Rere^flox/flox;Tie2-Cre embryos. These results suggest that decreased expression of RERE in cells other than the endocardium play a role in regulating the expression of GATA4 in the AV canal. Arrows and dashed lines indicate the AV endocardial cushions. Representative images are shown from the analysis of sections from three embryos of each genotype. Scale bars: 100 µm.