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. 2018 Sep 27;11(9):dmm035089. doi: 10.1242/dmm.035089

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© 2018. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 2. — Postsymptom antitoxin treatment is fully protective in rabbits intoxicated with BoNT/A, but not in those intoxicated with BoNT/B. Rabbits were exposed to 4 RbIMLD₅₀ of BoNT/A or BoNT/B, and antitoxin (215 IU/kg) was administered intravenously immediately after the onset of spirometry symptoms. Each plotted symbol (o, survival; x, death) refers to an individual animal. The dashed line represents the latest time point (36 h) at which symptomatic rabbits were fully protected by antitoxin treatment. Data were collected from at least three independent experiments. Each experiment included negative control (toxin only) rabbits. TTS values of accompanying negative control (toxin only) rabbits (n=8, 42.25±1.19 h and 41.75±1.32 h for BoNT/A and BoNT/B, respectively) were comparable to those of antitoxin-treated rabbits.