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. 2018 Aug 23;11(9):dmm035576. doi: 10.1242/dmm.035576

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© 2018. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 8. — ZA increases bone mineralisation in p62^P394L+/+ mice. 4-month-old female p62^P394L+/+ mice were treated with ZA (n=8) or vehicle (PBS, n=7) at 2 month intervals until the age of 12 months. Bone mineralisation was assessed at the same level in the diaphysis of the femoral bones. (A) The ZA-treated mice have highly mineralised bones compared with the vehicle-treated controls. (B) The bone tissue mineral density (TMD) is significantly higher in the ZA-treated mice compared with controls. The graph shows the density distribution within the bone tissue. The samples from ZA-treated mice show significantly higher mean density, and a widening of the density distribution.