Day | Events |
---|---|
1 | Patient experiences syncope after sexual activity on reaching orgasm. After tapping her face, consciousness was recovered within seconds, and she was transferred to our Cardiology unit by the emergency services |
Physical examination and laboratory investigations revealed no abnormalities | |
Baseline 12 lead electrocardiogram revealed a wide based T-wave with a prolonged QT interval of 520 ms with a heart rate of 56 b.p.m. | |
3 | Patient became tachypneuic, dizzy and was unresponsive for a few seconds. Runs of torsades de pointes were recorded simultaneously on telemetry |
Magnesium was administered intravenously | |
A beta-blocker (metoprolol) was started | |
8 | Patient was treated with an implantable cardioverter-defibrillator |
35 | Genetic testing revealed a mutation in the KCNH2 gene encoding the alpha-subunit of the delayed rectifier potassium channel |